Antioxidant, anticancer and antimicrobial activity of secondary metabolites from Fusarium species

Authors

  • Rita de Nazaré Silva Alves
  • Kátia Regina Assunção Borges
  • Marcos Antonio Custódio Neto da Silva
  • Amanda Mara Teles
  • Diamantino Alves
  • Gilza Maria Piedade Prazeres
  • Cáritas de Jesus Silva Mendonça
  • Marcos Bispo Pinheiro Câmara
  • Marcelo Souza de Andrade
  • Maria do Desterro Soares Brandão Nascimento
  • Geusa Felipa de Barros Bezerra

DOI:

https://doi.org/10.55905/oelv22n5-068

Keywords:

Fusarium, Secondary Metabolite, Biological Activity, Antioxidant Activity

Abstract

To evaluate the biological activities of secondary metabolites obtained from Fusarium species. The secondary metabolites of Fusarium oxysporum showed a proliferative effect on MCF-7 cells. The secondary metabolites of Fusarium solani reduced the viability of the MCF-7 cell in 48 hours. The metabolites of both fungi showed significant antibacterial activity (p<0.0010) in E. coli strains at all concentrations. F.oxysporum and solani significantly inhibited S. aureus at all concentrations within 24h. F. oxysporum metabolites significantly reduced C. albicans at all concentrations within 24h. The secondary metabolites of Fusarium solani significantly (p<0.0001) reduced the viability of C. albicans at all concentrations. There are compounds in Fusarium solani with antitumor and antimicrobial properties.

References

CHOWDHURY, Nargis Sultana; SOHRAB, Md Hossain; RANA, Md Sohel; HASAN, Choudhury Mahmood; JAMSHIDI, Shirin; RAHMAN, Khondaker Miraz. Cytotoxic Naphthoquinone and Azaanthraquinone Derivatives from an Endophytic Fusarium solani. Journal of Natural Products, [S. l.], v. 80, n. 4, p. 1173–1177, 2017. ISSN: 15206025. DOI: 10.1021/acs.jnatprod.6b00610.

Clinical and Laboratory Standards Institute. Performance Standards for Antimicrobial Susceptibility Testing 26 (2015).

GONÇALVES, Brisa; BASTOS, Eduardo; HANNA, Samira. Prospecção Tecnológica De Fungos Endófitos E Aplicações Na Indústria Farmacêutica. Cadernos de Prospecção, [S. l.], v. 10, n. 1, p. 56, 2017. ISSN: 1983-1358. DOI: 10.9771/cp.v10i1.20114.

GRECO, Claudio; KELLER, Nancy P.; ROKAS, Antonis. Unearthing fungal chemodiversity and prospects for drug discovery. Current Opinion in Microbiology, [S. l.], v. 51, p. 22–29, 2019. ISSN: 18790364. DOI: 10.1016/j.mib.2019.03.002. Disponível em: https://doi.org/10.1016/j.mib.2019.03.002.

IBRAHIM, Sabrin Ragab Mohamed; ELKHAYAT, Ehab Saad; MOHAMED, Gamal Abd Allah; FAT’HI, Shaukat Mohammed; ROSS, Samir Anis. Fusarithioamide A, a new antimicrobial and cytotoxic benzamide derivative from the endophytic fungus Fusarium chlamydosporium. Biochemical and Biophysical Research Communications, [S. l.], v. 479, n. 2, p. 211–216, 2016. ISSN: 10902104. DOI: 10.1016/j.bbrc.2016.09.041. Disponível em: http://dx.doi.org/10.1016/j.bbrc.2016.09.041.

INSTITUTO NACIONAL DE CÂNCER JOSÉ ALENCAR GOMES DA SILVA. Estimativa 2020 : incidência de câncer no Brasil / Instituto Nacional de Câncer José Alencar Gomes da Silva. – Rio de Janeiro : INCA, 2019.

KASAEI, Abdollah; MOBINI-DEHKORDI, Mohsen; MAHJOUBI, Foruzandeh; SAFFAR, Behnaz. Isolation of Taxol-Producing Endophytic Fungi from Iranian Yew Through Novel Molecular Approach and Their Effects on Human Breast Cancer Cell Line. Current Microbiology, [S. l.], v. 74, n. 6, p. 702–709, 2017. ISSN: 14320991. DOI: 10.1007/s00284-017-1231-0.

KHAN, Nasima; AFROZ, Farhana; BEGUM, Mst Nadira; ROY RONY, Satyajit; SHARMIN, Suriya; MONI, Fatema; MAHMOOD HASAN, Choudhury; SHAHA, Koushik; SOHRAB, Md Hossain. Endophytic Fusarium solani: A rich source of cytotoxic and antimicrobial napthaquinone and aza-anthraquinone derivatives. Toxicology Reports, [S. l.], v. 5, n. September, p. 970–976, 2018. ISSN: 22147500. DOI: 10.1016/j.toxrep.2018.08.016. Disponível em: https://doi.org/10.1016/j.toxrep.2018.08.016.

KYEKYEKU, James Oppong; KUSARI, Souvik; ADOSRAKU, Reimmel Kwame; BULLACH, Anke; GOLZ, Christopher; STROHMANN, Carsten; SPITELLER, Michael. Antibacterial secondary metabolites from an endophytic fungus, Fusarium solani JK10. Fitoterapia, [S. l.], v. 119, n. February, p. 108–114, 2017. ISSN: 18736971. DOI: 10.1016/j.fitote.2017.04.007. Disponível em: http://dx.doi.org/10.1016/j.fitote.2017.04.007.

MAHMOUD, Mohamed A.; SHEHATA, Shereen M.Molecular identification and characterization of Fusarium spp. associated with wheat grains Int. J. Adv. Res. Biol. Sci. (2017). 4(4): 77-87

MENSOR, L. L., REIS, A. S., MENEZES, F. S., LEITÃO, G. G., COUBE, C. S. & SANTOS, T. C. 2001. Screening of Brazilian plant extracts for antioxidant activity by the use of DPPH free radical method. Phytotherapy Research, 15 (2): 127-130

MOSUNOVA, Olga; NAVARRO-MUÑOZ, Jorge C.; COLLEMARE, Jérôme. The Biosynthesis of Fungal Secondary Metabolites: From Fundamentals to Biotechnological Applications. Reference Module in Life Sciences, [S. l.], p. 1–19, 2020. ISBN: 9780128096338. DOI: 10.1016/b978-0-12-809633-8.21072-8.

PATHAK, Ayush; NOWELL, Reuben W.; WILSON, Christopher G.; RYAN, Matthew J.; BARRACLOUGH, Timothy G. Comparative genomics of Alexander Fleming’s original Penicillium isolate (IMI 15378) reveals sequence divergence of penicillin synthesis genes. Scientific Reports, [S. l.], v. 10, n. 1, p. 1–10, 2020. ISSN: 20452322. ISBN: 0123456789. DOI: 10.1038/s41598-020-72584-5. Disponível em: https://doi.org/10.1038/s41598-020-72584-5.

RANI, Priyanka; PAL, Dilipkumar; HEGDE, Rahul Rama; HASHIM, Syed Riaz. Anticancer, anti-inflammatory, and analgesic activities of synthesized 2-(substituted phenoxy) acetamide derivatives. BioMed Research International, [S. l.], v. 2014, 2014. ISSN: 23146141. DOI: 10.1155/2014/386473.

SALEHI, Behzad; BAYAT, Mansour; DEZFULIAN, Mehrouz; SABOKBAR, Azar; TABARAIE, Bahman. The assessment of anti-tumoral activity of polysaccharide extracted from terrestrial filamentous fungus. Saudi Journal of Biological Sciences, [S. l.], v. 25, n. 6, p. 1236–1241, 2018. ISSN: 1319562X. DOI: 10.1016/j.sjbs.2016.06.002. Disponível em: https://doi.org/10.1016/j.sjbs.2016.06.002.

STROBEL, Gary. The emergence of endophytic microbes and their biological promise. Journal of Fungi, [S. l.], v. 4, n. 2, 2018. ISSN: 2309608X. DOI: 10.3390/jof4020057.

Tadpetch, K., Chukong, C., Jeanmard, L., Thiraporn, A., Rukachaisirikul, V., Phongpaichit, S., & Sakayaroj, J. (2015). Cytotoxic naphthoquinone and a new succinate ester from the soil fungus Fusarium solani PSU-RSPG227. Phytochemistry Letters, 11, 106–110. doi:10.1016/j.phytol.2014.11.

TAKAHASHI, Jacqueline A.; LIMA, Gesiane da S.; SANTOS, Gabriel F. Dos; LYRA, Fernanda H.; SILVA-HUGHES, Alice F. Da; GONÇALVES, Flávia A. G. Fungos Filamentosos e Química: Velhos Conhecidos, Novos Aliados. Revista Virtual da Química, [S. l.], v. 9, n. 6, p. 2351–2382, 2017. Disponível em: http://rvq.sbq.org.br.

TELES, Amanda Mara; EVERTON, Gustavo Oliveira; MOUCHREK, Adenilde Nascimento; TELLIS, Carla Junqueira Moragas; BEZERRA, Geusa Felipa de Barros; SOUZA, Fernando Almeida De; SANTOS, Ana Paula Silva de Azevedo-;NASCIMENTO, Maria do Desterro Soares Brandão. Triagem fitoquímica de extrato obtido do fungo Penicillium purpurogenum advindo de ambiente marinho poluído do Maranhão. Research, Society and Development, [S. l.], v. 9, n. 8, 2020. ISSN: 2525-3409. DOI: 10.33448/rsd-v9i8.6109.

TOGHUEO, Rufin Marie Kouipou. Bioprospecting endophytic fungi from Fusarium genus as sources of bioactive metabolites. Mycology, [S. l.], v. 11, n. 1, p. 1–21, 2020. ISSN: 21501211. DOI: 10.1080/21501203.2019.1645053.

VUOLO, Milena Morandi; LIMA, Verena Silva; ROBERTO, Mário; JUNIOR, Maróstica. Classification , and Antioxidant Power. [s.l.] : Elsevier Inc., 2019. ISBN: 9780128147740. DOI: 10.1016/B978-0-12-814774-0.00002-5. Disponível em: https://doi.org/10.1016/B978-0-12-814774-0.00002-5.

WORLD HEALTH ORGANIZATION (WHO). WHO Director-General calls for all countries to take action to help end the suffering caused by cervical cancer. WHO;2018. Acess in June 2020.

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Published

2024-05-08

How to Cite

Alves, R. de N. S., Borges, K. R. A., Silva, M. A. C. N. da, Teles, A. M., Alves, D., Prazeres, G. M. P., Mendonça, C. de J. S., Câmara, M. B. P., Andrade, M. S. de, Nascimento, M. do D. S. B., & Bezerra, G. F. de B. (2024). Antioxidant, anticancer and antimicrobial activity of secondary metabolites from Fusarium species. OBSERVATÓRIO DE LA ECONOMÍA LATINOAMERICANA, 22(5), e4578. https://doi.org/10.55905/oelv22n5-068

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