Biotechnological potential of Aspergillus niger L-asparaginase supplemented with Euterpe oleracea mart seed as an alternative source for cervical cancer treatment: a literature review


  • Suzane Meriely da Silva Duarte
  • Allysson Kayron de Carvalho Silva
  • Vivian Cassia Tavares Cardoso Nahon
  • Miquéias de Oliveira Martins
  • André Alvares Marques Vale
  • Marcos Antônio Custódio Neto da Silva
  • Maria do Desterro Soares Brandão Nascimento



Aspergillus niger, L-asparaginase, Euterpe oleracea Mart, human Papillomavirus


According to the Pan American Health Organization (PAHO), cancer is one of the leading causes of death in the Americas, with cervical cancer being the third most common, affecting over 56 thousand women in Latin America, and unfortunately, over 28 thousand of them do not survive this disease. This review study aims to present the enzyme L-asparaginase produced by the fungus Aspergillus niger, supplemented with the seed of Euterpe oleracea Mart (açaí), as an alternative treatment source against cervical cancer caused by human papillomavirus (HPV), thus encouraging biotechnological studies with natural products, promoting future benefits that significantly contribute to the treatment of women affected by HPV. Much research has been conducted on the species of fungus Aspergillus niger, which are widely distributed in nature and have the ability to produce various metabolites, notably L-asparaginase. In this sense, studies confirming the efficacy of this enzyme against HPV could signify a breakthrough in the remission or cure of cervical cancer cases in women with such a diagnosis. The flour from the seed of Euterpe oleracea Mart, when used as a substrate for Aspergillus niger, may possess excellent nutritional value, making it a potential producer of L-asparaginase. Additionally, the pulp of E. oleracea fruits is a source of agro-industrial waste, and with the opportunity for utilization, it becomes a source of promising substances for commercial use. This review sought to present L-asparaginase produced by a natural fungus (Aspergillus niger) as an alternative source for in-depth studies on its potential for treating HPV-induced cervical cancer, discussing the use of Euterpe oleracea Mart seed as a supplement for this fungus, drawing attention to the utilization of this agro-industrial waste and proposing a reduction in environmental pollution.


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How to Cite

Duarte, S. M. da S., Silva, A. K. de C., Nahon, V. C. T. C., Martins, M. de O., Vale, A. A. M., da Silva, M. A. C. N., & Nascimento, M. do D. S. B. (2024). Biotechnological potential of Aspergillus niger L-asparaginase supplemented with Euterpe oleracea mart seed as an alternative source for cervical cancer treatment: a literature review. OBSERVATÓRIO DE LA ECONOMÍA LATINOAMERICANA, 22(2), e3519.




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