Spectroscopic and thermal characterization of pyrantel pamoate ap-plied to solid pharmaceutical formulations

Authors

  • Cristian Arlenson Delacruz
  • Rosane Aguiar da Silva San Gil
  • Mateus Marinho Baptista
  • Leandro Bandeira Borré

DOI:

https://doi.org/10.55905/oelv21n11-164

Keywords:

pyrantel pamoate, X-ray diffraction, infrared spectroscopy, 13C CPMAS NMR, thermal analysis, pharmaceutical formulations

Abstract

In this study, we have used various techniques to characterize the spectroscopic and thermal behavior of Pyrantel Pamoate (PP), an anthelmintic drug classified as an essential drug by the World Health Organization for the treatment of parasitic worm infections, as powder X-ray Diffraction (XRD), Fourier Transformed Infrared Spectroscopy (FTIR), Solid State NMR (13C CPMAS NMR), thermogravimetric analysis (TG), derivative thermogravimetry (DTG) and differential scanning calorimetry (DSC) at two different heating rates (2 and 10 K.min-1) under an inert gas flow. We analyzed a USP standard sample of PP, which allowed us to characterize it. Additionally, we examined four commercial solid formulations of PP purchased from Colombian pharmacies to provide evidence of any potential contaminants or adulteration. Our results confirmed the authenticity of the standard sample and identified PP as the active ingredient in all four Colombian products. By combining these analytical techniques, we were able to provide a comprehensive characterization of PP and potential issues with commercial formulations.

References

AGUIAR, D.L.M.; SAN GIL, R.A.S.; BORRÉ, L.B.; MARQUES, M.R.C.; GEMAL, A.L. Evaluation of polymorphs in cephalexin medicines by 13C solid state NMR. International Journal of Pharmacy and Pharmaceutical Sciences, v.3, pp.293-298, 2011.

AGUIAR, M.R.M.P.; GEMAL, A.L.; SAN GIL, R.A.S. Characterization of polymorphism in pharmaceuticals by solid-state nuclear magnetic resonance. Quim. Nva, v.22, pp.553-564, 1999.

AMES, J.; SOUZA, D.Z. Falsificação de medicamentos no Brasil, Rev. Saude Publica, vol. 46, pp. 154–159, 2012. Doi:10.1590/s0034-89102012005000005.

DELACRUZ, C.A. Caracterização e quantificação de pamoato de pirantel em formulações por ressonância magnética nuclear de sólidos, Dissertação de Mestrado, Universidade Federal do Rio de Janeiro, Instituto de Química, 2021.

DRUGS.COM, Pyrantel Pamoate Monograph, Drugs.com, 2019. [Online]. Available: https://www.drugs.com/monograph/pyrantel-pamoate.html. [Accessed: 15-Jan-2020].

GABBOTT, P. Principles and Applications of Thermal Analysis. Ames Iowa: Blackwell Publishing Ltd, 2008.

GARCÍA, G. Caracterización del Pamoato de Pirantel por técnicas espectroscópicas, térmicas y difractométricas. Análisis de medicamentos con este principio farmacéutico, PhD Thesis, Universidad de los Andes, 2009.

LIMA, G. Caracterização no estado sólido dos polimorfos de tibolona, Tese de Doutorado, Universidade de São Paulo, 2009.

MOJUMDAR, S.C.; SAIN, M.; PRASAD, R.C.; SUN, L.; VENART, J.E.S. Selected thermoanalytical methods and their applications from medicine to construction: Part I, J. Therm. Anal. Calorim., vol. 90, pp. 653–662, 2007. Doi:10.1007/s10973-007-8518-5.

NTP, Pyrantel pamoate, PubChem, 1992. [Online]. Available: https://pubchem.ncbi.nlm.nih.gov/compound/pyrantel_pamoate#section=Melting-Point. [Accessed: 15-Jan-2022].

OLIVEIRA, M. A.; YOSHIDA, M.I.; GOMES, E.C.L. Análise térmica aplicada a fármacos e formulações farmacêuticas na industria farmacêutica, Quim. Nova, vol. 34, pp. 1224–1230, 2011. Doi:10.1590/S0100-40422011000700022.

OZAWA, T. Thermal analysis - review and prospect. Thermochimica Acta, v.355, pp. 35 - 42, 2000.

PIANTAVINI, M.S.; PONTES, F.L.D.; WEISS, L.X.; SENA, M.M.; PONTAROLO, R. Comparison between ultraviolet and infrared spectroscopies for the simultaneous multivariate determination of pyrantel and praziquantel, J. Braz. Chem. Soc., vol. 26, pp. 1387–1395, 2015. DOI:10.5935/0103-5053.20150107.

SILVA, R.P.; AMBRÓSIO, M.F.S.; PIOVESN, L.A.; FREITAS, M.C.R.; AGUIAR, D.L.M.; HORTA, B.A.C.; EPPRECHT, E.K.; SAN GIL, R.A.S.; VISENTIN, L.C. New polymorph form of dexamethasone acetate. Journal of Pharmaceutical Sciences, v.107, pp.672-681, 2018.

VAN DOOREN, A.A.; MÜLLER, B.W. Purity determinations of drugs with differential scanning calorimetry (DSC)-a critical review, Int. J. Pharm., vol. 20, pp. 217–233, 1984. Doi:10.1016/0378-5173(84)90170-4.

WHO, WHO Model Lists of Essential Medicines,World Health Organization, 2019. [Online].Available: https://www.who.int/medicines/publications/essentialmedicines/en/. [Accessed: 14-Oct-2023].

WILEY, J. & SONS (n.d.) Pyrantel Pamoate - FTIR Spectrum, SpectraBase.com. Retrieved July 21, 2023, from https://spectrabase.com/compound/CFpALNKYB0I#products.

Downloads

Published

2023-11-24

How to Cite

Delacruz, C. A., Gil, R. A. da S. S., Baptista, M. M., & Borré, L. B. (2023). Spectroscopic and thermal characterization of pyrantel pamoate ap-plied to solid pharmaceutical formulations. OBSERVATÓRIO DE LA ECONOMÍA LATINOAMERICANA, 21(11), 21607–21626. https://doi.org/10.55905/oelv21n11-164

Issue

Section

Articles