Remodeladores da cromatina: alterações moleculares e farmacogenômica
DOI:
https://doi.org/10.55905/oelv21n9-139Keywords:
alterações moleculares, câncer, remodeladores da cromatinaAbstract
A associação do ácido desoxirribonucleico (DNA) compactado com proteínas forma um complexo denominado de cromatina, que condensa o DNA dentro do núcleo celular e controla diversos aspectos do seu funcionamento. Alterações nos genes de remodelamento da cromatina podem levar ao surgimento do câncer e afetar diretamente os mecanismos de resistência e progressão do paciente. Neste sentido, foram identificadas alterações moleculares em genes envolvidos no remodelamento da cromatina e suas potenciais implicações na resposta à fármacos, bem como a frequência que estes estão alterados em amostras de canceres. As análises foram realizadas “in silico”, utilizando linguagem de programação R para explorar os dados do painel de linhagens celulares NCI-60 (“National Cancer Institute Panel of Cancer Cells”). Após analisar os 90 genes remodeladores da cromatina percebeu-se que a posição cromossômica, família gênica e função molecular desempenham um papel relevante na determinação da expressão destes genes. Além disso, a família SWI/SNF apresentou alta incidência de alterações moleculares no painel NCI-60, sugerindo que a inativação de membros desta família pode desempenhar um papel importante no desenvolvimento neoplásico. Por sua vez, a expressão gênica, bem como as alterações moleculares mostraram-se associadas a atividade de vários fármacos sugerindo novas potenciais aplicações clínicas na terapia personalizada.
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